Loading...
 
Toggle Health Problems and D

Vitamin D and Cancer - Jan 2024

Vitamin D and potential effects on cancers: a review

Mol Biol Rep. 2024 Jan 25;51(1):190. doi: 10.1007/s11033-023-09111-y
PDF is behind a paywall. Can be viewed at DeepDyve
Pouria Sobhi 1, Mohammad Bahrami 1, Faraz Mahdizadeh 1, Aliakbar Fazaeli 2, Ghader Babaei 3, Lotfollah Rezagholizadeh 4

Vitamin D is common to 4 concerns
Image
Cancer is characterized by the abnormal and uncontrollable division and growth of cells that can infiltrate tissues and alter normal physiological function, which will become crucial and life-threatening if left untreated. Cancer can be a result of genetics, such as mutations or environmental causes, including smoking, lack of physical activity, as well as nutritional imbalance in the body. Vitamin D is one of the foremost nutrients that play a crucial role in a variety of biochemical pathways, and it is an important key factor in several diseases. Vitamin D is an essential nutrient for preventing malignancies and a complementary treatment for cancer through direct and indirect biochemical pathways. In this article, we summarized the correlation between vitamin D and various cancers using an extensive search on PubMed, Google Scholar, and Scopus. This paper reviews the role of vitamin D in different types of cancer.

99 References
  1. Christakos S et al (2010) Vitamin D: metabolism. Endocrinol Metab Clin North Am 39(2):243–253 (table of contents) - PubMed - PMC - DOI
  2. Carlberg C (2019) Vitamin D: a micronutrient regulating genes. Curr Pharm Des 25(15):1740–1746 - PubMed - DOI
  3. Wang Y, Zhu J, DeLuca HF (2012) Where is the vitamin D receptor? Arch Biochem Biophys 523(1):123–133 - PubMed - DOI
  4. Akimbekov NS et al (2022) Vitamin D and phosphate interactions in health and disease. Adv Exp Med Biol 1362:37–46 - PubMed - DOI
  5. Holick MF et al (2011) Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 96(7):1911–1930 - PubMed - DOI
  6. Chang EM et al (2014) Association between sex steroids, ovarian reserve, and vitamin D levels in healthy nonobese women. J Clin Endocrinol Metab 99(7):2526–2532 - PubMed - DOI
  7. Zanatta L et al (2011) Nongenomic and genomic effects of 1alpha,25(OH)2 vitamin D3 in rat testis. Life Sci 89(15–16):515–523 - PubMed - DOI
  8. Zhao D et al (2017) Serum vitamin D and sex hormones levels in men and women: the Multi-Ethnic Study of Atherosclerosis (MESA). Maturitas 96:95–102 - PubMed - DOI
  9. Bergengren O et al (2023) 2022 update on prostate cancer epidemiology and risk factors—a systematic review. Eur Urol 84(2):191–206 - PubMed - DOI
  10. Song ZY et al (2018) Circulating vitamin D level and mortality in prostate cancer patients: a dose-response meta-analysis. Endocr Connect 7(12):R294–R303 - PubMed - PMC - DOI
  11. Capiod T et al (2018) Do dietary calcium and vitamin D matter in men with prostate cancer? Nat Rev Urol 15(7):453–461 - PubMed - DOI
  12. Bao BY, Yeh SD, Lee YF (2006) 1alpha,25-dihydroxyvitamin D3 inhibits prostate cancer cell invasion via modulation of selective proteases. Carcinogenesis 27(1):32–42 - PubMed - DOI
  13. Woo TC et al (2005) Pilot study: potential role of vitamin D (Cholecalciferol) in patients with PSA relapse after definitive therapy. Nutr cancer 51(1):32–36 - PubMed - DOI
  14. Bernichtein S et al (2017) Vitamin D3 prevents calcium-induced progression of early-stage prostate tumors by counteracting TRPC6 and calcium sensing receptor upregulation. cancer Res 77(2):355–365 - PubMed - DOI
  15. Barreto AM et al (2000) 25-Hydroxyvitamin D3, the prohormone of 1,25-dihydroxyvitamin D3, inhibits the proliferation of primary prostatic epithelial cells. cancer Epidemiol Biomarkers Prev 9(3):265–270 - PubMed
  16. Gupta D et al (2009) Vitamin D and prostate cancer risk: a review of the epidemiological literature. Prostate cancer Prostatic Dis 12(3):215–226 - PubMed - DOI
  17. Tuohimaa P et al (2004) Both high and low levels of blood vitamin D are associated with a higher prostate cancer risk: a longitudinal, nested case-control study in the Nordic countries. Int J cancer 108(1):104–108 - PubMed - DOI
  18. Gao J et al (2018) Circulating vitamin D concentration and risk of prostate cancer: a dose-response meta-analysis of prospective studies. Ther Clin Risk Manag 14:95–104 - PubMed - PMC - DOI
  19. Wilkinson L, Gathani T (2022) Understanding breast cancer as a global health concern. Br J Radiol 95(1130):20211033 - PubMed - DOI
  20. Mittal MK et al (2008) In vivo binding to and functional repression of the VDR gene promoter by SLUG in human breast cells. Biochem Biophys Res Commun 372(1):30–34 - PubMed - PMC - DOI
  21. Liu X et al (2018) miR-1204 targets VDR to promotes epithelial-mesenchymal transition and metastasis in breast cancer. Oncogene 37(25):3426–3439 - PubMed - DOI
  22. Larriba MJ, Garcia de Herreros A, Munoz A (2016) Vitamin D and the epithelial to mesenchymal transition. Stem Cells Int 2016:6213872 - PubMed - PMC - DOI
  23. Lopes N et al (2012) 1Alpha,25-dihydroxyvitamin D3 induces de novo E-cadherin expression in triple-negative breast cancer cells by CDH1-promoter demethylation. Anticancer Res 32(1):249–257 - PubMed
  24. Wilmanski T et al (2016) 1alpha,25-dihydroxyvitamin D inhibits the metastatic capability of MCF10CA1a and MDA-MB-231 cells in an in vitro model of breast to bone metastasis. Nutr cancer 68(7):1202–1209 - PubMed - PMC - DOI
  25. Koli K, Keski-Oja J (2000) 1alpha,25-dihydroxyvitamin D3 and its analogues down-regulate cell invasion-associated proteases in cultured malignant cells. Cell Growth Differ 11(4):221–229 - PubMed
  26. Li J et al (2021) Vitamin D regulates CXCL12/CXCR4 and epithelial-to-mesenchymal transition in a model of breast cancer metastasis to lung. Endocrinology. https://doi.org/10.1210/endocr/bqab049 - DOI - PubMed - PMC
  27. Anisiewicz A et al (2018) Unfavorable effect of calcitriol and its low-calcemic analogs on metastasis of 4T1 mouse mammary gland cancer. Int J Oncol 52(1):103–126 - PubMed
  28. Anisiewicz A et al (2019) Calcitriol analogues decrease lung metastasis but impair bone metabolism in aged ovariectomized mice bearing 4T1 mammary gland tumours. Aging Dis 10(5):977–991 - PubMed - PMC - DOI
  29. Vanhevel J et al (2022) The role of vitamin D in breast cancer risk and progression. Endocr Relat cancer 29(2):R33–R55 - PubMed - DOI
  30. Filip-Psurska B et al (2022) Vitamin D, Th17 lymphocytes, and breast cancer. cancers 14(15):3649 - PubMed - PMC - DOI
  31. Krishnan AV et al (2010) Tissue-selective regulation of aromatase expression by calcitriol: implications for breast cancer therapy. Endocrinology 151(1):32–42 - PubMed - DOI
  32. Swami S et al (2011) Inhibitory effects of calcitriol on the growth of MCF-7 breast cancer xenografts in nude mice: selective modulation of aromatase expression in vivo. Horm cancer 2(3):190–202 - PubMed - PMC - DOI
  33. Vink-van Wijngaarden T et al (1994) Inhibition of breast cancer cell growth by combined treatment with vitamin D3 analogues and tamoxifen. cancer Res 54(21):5711–5717 - PubMed
  34. Lim ST et al (2018) Synergistic anticancer effects of ruxolitinib and calcitriol in estrogen receptor-positive, human epidermal growth factor receptor 2-positive breast cancer cells. Mol Med Rep 17(4):5581–5588 - PubMed - PMC
  35. Friedrich M et al (2018) Effects of combined treatment with vitamin D and COX2 inhibitors on breast cancer cell lines. Anticancer Res 38(2):1201–1207 - PubMed
  36. Segovia-Mendoza M et al (2017) The addition of calcitriol or its synthetic analog EB1089 to lapatinib and neratinib treatment inhibits cell growth and promotes apoptosis in breast cancer cells. Am J cancer Res 7(7):1486–1500 - PubMed - PMC
  37. Tavera-Mendoza LE et al (2017) Vitamin D receptor regulates autophagy in the normal mammary gland and in luminal breast cancer cells. Proc Natl Acad Sci USA 114(11):E2186–E2194 - PubMed - PMC - DOI
  38. Estebanez N et al (2018) Vitamin D exposure and Risk of Breast cancer: a meta-analysis. Sci Rep 8(1):9039 - PubMed - PMC - DOI
  39. Song D et al (2019) Vitamin D intake, blood vitamin D levels, and the risk of breast cancer: a dose-response meta-analysis of observational studies. Aging 11(24):12708–12732 - PubMed - PMC - DOI
  40. Vaughan-Shaw PG et al (2017) The impact of vitamin D pathway genetic variation and circulating 25-hydroxyvitamin D on cancer outcome: systematic review and meta-analysis. Br J cancer 116(8):1092–1110 - PubMed - PMC - DOI
  41. Hossain S et al (2019) Vitamin D and breast cancer: a systematic review and meta-analysis of observational studies. Clin Nutr ESPEN 30:170–184 - PubMed - PMC - DOI
  42. Crew KD et al (2019) Randomized double-blind placebo-controlled biomarker modulation study of vitamin D supplementation in premenopausal women at high risk for breast cancer (SWOG S0812). cancer Prev Res 12(7):481–490 - DOI
  43. Crew KD et al (2009) Association between plasma 25-hydroxyvitamin D and breast cancer risk. cancer Prev Res 2(6):598–604 - DOI
  44. Qin B et al (2020) Intake of vitamin D and calcium, sun exposure, and risk of breast cancer subtypes among black women. Am J Clin Nutr 111(2):396–405 - PubMed - DOI
  45. Manson JE et al (2019) Vitamin D supplements and prevention of cancer and cardiovascular disease. N Engl J Med 380(1):33–44 - PubMed - DOI
  46. Chandler PD et al (2020) Effect of vitamin D3 supplements on development of advanced cancer: a secondary analysis of the VITAL randomized clinical trial. JAMA Netw Open 3(11):e2025850 - PubMed - PMC - DOI
  47. Lappe J et al (2017) Effect of vitamin D and calcium supplementation on cancer incidence in older women: a randomized clinical trial. JAMA 317(12):1234–1243 - PubMed - DOI
  48. Scragg RKR (2019) Overview of results from the Vitamin D assessment (ViDA) study. J Endocrinol Investig 42(12):1391–1399 - DOI
  49. Arnaout A et al (2019) Randomized window of opportunity trial evaluating high-dose vitamin D in breast cancer patients. Breast cancer Res Treat 178(2):347–356 - PubMed - DOI
  50. Li Z et al (2021) Effect of vitamin D supplementation on risk of breast cancer: a systematic review and meta-analysis of randomized controlled trials. Front Nutr 8:655727 - PubMed - PMC - DOI
  51. Voutsadakis IA (2021) Vitamin D baseline levels at diagnosis of breast cancer: A systematic review and meta-analysis. Hematol Oncol Stem Cell Ther 14(1):16–26 - PubMed - DOI
  52. O’Brien KM et al (2018) Vitamin D, DNA methylation, and breast cancer. Breast cancer Res 20(1):70 - PubMed - PMC - DOI
  53. Simmons KM et al (2015) Gene signatures of 1,25-dihydroxyvitamin D3 exposure in normal and transformed mammary cells. J Cell Biochem 116(8):1693–1711 - PubMed - PMC - DOI
  54. O’Brien KM et al (2022) Vitamin D supplement use and risk of breast cancer by race-ethnicity. Epidemiology 33(1):37–47 - PubMed - PMC - DOI
  55. Sheng L, Callen DF, Turner AG (2018) Vitamin D(3) signaling and breast cancer: insights from transgenic mouse models. J Steroid Biochem Mol Biol 178:348–353 - PubMed - DOI
  56. Bauer SR et al (2013) Plasma vitamin D levels, menopause, and risk of breast cancer: dose-response meta-analysis of prospective studies. Medicine 92(3):123–131 - PubMed - PMC - DOI
  57. Lewandowska A et al (2022) Risk factors for the diagnosis of colorectal cancer. Cancer Control 29:10732748211056692 - PubMed - PMC - DOI
  58. Klampfer L (2014) Vitamin D and colon cancer. World J Gastrointest Oncol 6(11):430–437 - PubMed - PMC - DOI
  59. Ferrer-Mayorga G et al (2019) Mechanisms of action of vitamin D in colon cancer. J Steroid Biochem Mol Biol 185:1–6 - PubMed - DOI
  60. Khayami R et al (2022) Epigenomic effects of vitamin D in colorectal cancer. Epigenomics 14(19):1213–1228 - PubMed - DOI
  61. Huang CY et al (2022) Bioactive vitamin D attenuates MED28-mediated cell growth and epithelial-mesenchymal transition in human colorectal cancer cells. Biomed Res Int 2022:2268818 - PubMed - PMC - DOI
  62. Varghese JE (2020) Role of vitamin D3 on apoptosis and inflammatory-associated gene in colorectal cancer: an in vitro approach. J King Saud Univ Sci 32(6):2786–2789 - DOI
  63. Lamprecht SA, Lipkin M (2003) Chemoprevention of colon cancer by calcium, vitamin D and folate: molecular mechanisms. Nat Rev cancer 3(8):601–614 - PubMed - DOI
  64. Timar J, Ladanyi A (2022) Molecular pathology of skin melanoma: epidemiology, differential diagnostics, prognosis and therapy prediction. Int J Mol Sci 23(10):5384 - PubMed - PMC - DOI
  65. Branisteanu DE et al (2023) Differences and similarities in epidemiology and risk factors for cutaneous and uveal melanoma. Medicina 59(5):943 - PubMed - PMC - DOI
  66. Zhou M et al (2016) Cause-specific mortality for 240 causes in China during 1990–2013: a systematic subnational analysis for the Global Burden of Disease Study 2013. Lancet 387(10015):251–272 - PubMed - DOI
  67. Veierod MB et al (2010) Sun and solarium exposure and melanoma risk: effects of age, pigmentary characteristics, and nevi. cancer Epidemiol Biomarkers Prev 19(1):111–120 - PubMed - DOI
  68. Gajos-Michniewicz A, Czyz M (2020) WNT signaling in melanoma. Int J Mol Sci 21(14):4852 - PubMed - PMC - DOI
  69. Holstein TW (2012) The evolution of the Wnt pathway. Cold Spring Harb Perspect Biol 4(7):a007922 - PubMed - PMC - DOI
  70. Chaiprasongsuk A et al (2019) Protective effects of novel derivatives of vitamin D(3) and lumisterol against UVB-induced damage in human keratinocytes involve activation of Nrf2 and p53 defense mechanisms. Redox Biol 24:101206 - PubMed - PMC - DOI
  71. Liyanage UE et al (2020) Is there a causal relationship between vitamin D and melanoma risk? A Mendelian randomization study. Br J Dermatol 182(1):97–103 - PubMed - DOI
  72. Millen AE et al (2004) Diet and melanoma in a case-control study. cancer Epidemiol Biomark Prev 13(6):1042–1051 - DOI
  73. van der Pols JC et al (2013) Vitamin D status and skin cancer risk independent of time outdoors: 11-year prospective study in an Australian community. J Investig Dermatol 133(3):637–641 - PubMed - DOI
  74. Saiag P et al (2015) Prognostic value of 25-hydroxyvitamin D3 levels at diagnosis and during follow-up in melanoma patients. J Natl cancer Inst 107(12):djv264 - PubMed - DOI
  75. Muralidhar S et al (2019) Vitamin D-VDR signaling inhibits Wnt/β-catenin-mediated melanoma progression and promotes antitumor immunity. cancer Res 79(23):5986–5998 - PubMed - DOI
  76. Becker AL et al (2021) The role of the vitamin D receptor in the pathogenesis, prognosis, and treatment of cutaneous melanoma. Front Oncol 11:743667 - PubMed - PMC - DOI
  77. Tang JY et al (2011) Calcium plus vitamin D supplementation and the risk of nonmelanoma and melanoma skin cancer: post hoc analyses of the women’s health initiative randomized controlled trial. J Clin Oncol 29(22):3078–3084 - PubMed - PMC - DOI
  78. Vasilovici AF et al (2019) Vitamin D receptor polymorphisms and melanoma. Oncol Lett 17(5):4162–4169 - PubMed
  79. Birke M et al (2020) Association of vitamin D receptor gene polymorphisms with melanoma risk: a meta-analysis and systematic review. Anticancer Res 40(2):583–595 - PubMed - DOI
  80. Samant H, Amiri HS, Zibari GB (2021) Addressing the worldwide hepatocellular carcinoma: epidemiology, prevention and management. J Gastrointest Oncol 12(Suppl 2):S361–S373 - PubMed - PMC - DOI
  81. McGlynn KA, Petrick JL, El-Serag HB (2021) Epidemiology of hepatocellular carcinoma. Hepatology 73(Suppl 1):4–13 - PubMed - DOI
  82. Provvisiero DP et al (2019) Vitamin D reverts resistance to the mTOR inhibitor everolimus in hepatocellular carcinoma through the activation of a miR-375/oncogenes circuit. Sci Rep 9(1):11695 - PubMed - PMC - DOI
  83. Huang J et al (2016) 1,25(OH)2D3 inhibits the progression of hepatocellular carcinoma via downregulating HDAC2 and upregulating P21(WAFI/CIP1). Mol Med Rep 13(2):1373–1380 - PubMed - DOI
  84. Hamilton JP et al (2014) Effects of vitamin D3 stimulation of thioredoxin-interacting protein in hepatocellular carcinoma. Hepatol Res 44(13):1357–1366 - PubMed - PMC - DOI
  85. Chen J et al (2016) Vitamin D deficiency promotes liver tumor growth in transforming growth factor-beta/Smad3-deficient mice through Wnt and toll-like receptor 7 pathway modulation. Sci Rep 6:30217 - PubMed - PMC - DOI
  86. Gilliland DG, Jordan CT, Felix CA (2004) The molecular basis of leukemia. Hematol Am Soc Hematol Educ Progr 2004(1):80–97 - DOI
  87. Lee HJ et al (2014) Low 25(OH) vitamin D3 levels are associated with adverse outcome in newly diagnosed, intensively treated adult acute myeloid leukemia. cancer 120(4):521–529 - PubMed - DOI
  88. Jackmann N et al (2020) Vitamin D status in children with leukemia, its predictors, and association with outcome. Pediatr Blood cancer 67(4):e28163 - PubMed - DOI
  89. Wang J et al (2008) Vitamin D3 induces autophagy of human myeloid leukemia cells. J Biol Chem 283(37):25596–25605 - PubMed - DOI
  90. Kricker A et al (2008) Personal sun exposure and risk of non Hodgkin lymphoma: a pooled analysis from the Interlymph Consortium. Int J cancer 122(1):144–154 - PubMed - DOI
  91. Shanafelt TD et al (2011) Vitamin D insufficiency and prognosis in chronic lymphocytic leukemia. Blood 117(5):1492–1498 - PubMed - PMC - DOI
  92. Gediz F et al (2020) A possible connection between circulating 25-hydroxy-vitamin D and molecular response in chronic myeloid leukemia. Bratisl Lek Listy 121(5):366–369 - PubMed
  93. Lokeshwar BL et al (1999) Inhibition of prostate cancer metastasis in vivo: a comparison of 1,23-dihydroxyvitamin D (calcitriol) and EB1089. cancer Epidemiol Biomarkers Prev 8(3):241–248 - PubMed
  94. Chen Y et al (2013) Vitamin D receptor inhibits nuclear factor kappaB activation by interacting with IkappaB kinase beta protein. J Biol Chem 288(27):19450–19458 - PubMed - PMC - DOI
  95. Kristal AR et al (2014) Plasma vitamin D and prostate cancer risk: results from the Selenium and Vitamin E cancer Prevention Trial. cancer Epidemiol Biomarkers Prev 23(8):1494–1504 - PubMed - PMC - DOI
  96. Jiang X et al (2019) Circulating vitamin D concentrations and risk of breast and prostate cancer: a Mendelian randomization study. Int J Epidemiol 48(5):1416–1424 - PubMed - DOI
  97. Albanes D et al (2011) Serum 25-hydroxy vitamin D and prostate cancer risk in a large nested case-control study. cancer Epidemiol Biomarkers Prev 20(9):1850–1860 - PubMed - PMC - DOI
  98. Protiva P et al (2016) Calcium and 1,25-dihydroxyvitamin D3 modulate genes of immune and inflammatory pathways in the human colon: a human crossover trial. Am J Clin Nutr 103(5):1224–1231 - PubMed - PMC - DOI
  99. Field S, Newton-Bishop JA (2011) Melanoma and vitamin D. Mol Oncol 5(2):197–214 - PubMed - PMC - DOI

VitaminDWiki – Cancer category contains:


Cancers get less Vitamin D when there is a poor Vitamin D Receptor

Vitamin D and Cancer - Jan 2024        
1682 visitors, last modified 02 Feb, 2024,
(Cached) Printer Friendly Follow this page for updates
Cancer 268
Page actions
Refresh Print
Edit Files 1

Attached files

ID Name Comment Uploaded Size Downloads
20741 Role.png admin 02 Feb, 2024 87.71 Kb 178